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Description
Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Palbociclib, was approved on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer. 
Chemical Structure
 
Chemical Name
6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 
SMILES Code
O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5 
Theoretical Analysis
XingMo Cat#:XM703 
Product Name:Palbociclib free base 
Synonyms:PD-0332991; PD 0332991; PD0332991; Palbociclib free base, brand name: Ibrance. 
CAS#:571190-30-2 (free base) 
Chemical Formula:C24H29N7O2 
Exact Mass:447.23827 
Molecular Weight:447.543 
Purity:>98% 
Technical Data

Appearance: Yellowsolid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4o for short term (days to weeks) or -20oC for long term (months to years).

Solubility: Soluble in DMSO, not in water

 



WARNING: This product is for research use only, not for human or veterinary use

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