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Description
PRN-1371 is a covalent, irreversible, highly selective FGFR1, 2, 3 and 4 inhibitor. PRN1371 inhibits all four FGFR isoforms and blocks aberrant FGFR kinase signaling. This broad profile is suitable to treat many tumor types, including but not limited to urothelial, squamous lung, gastric and hepatocellular carcinoma. 
Chemical Structure
 
Chemical Name
8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 
SMILES Code
O=[N+](C1=CC=C(NC)N=C1NC2=CC3=C(NN=C3)C=C2)[O-] 
Theoretical Analysis
XingMo Cat#:XM502 
Product Name:PRN1371 
Synonyms:PRN1371; PRN-1371; PRN 1371 
CAS#:1802929-43-6 
Chemical Formula:C26H30Cl2N6O4 
Exact Mass:560.1706 
Molecular Weight:561.464 
Purity:98% 
Technical Data
Appearance: Solid powder                               
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 oC for short term (days to weeks), or -20 oC for long term (months). 
 



WARNING: This product is for research use only, not for human or veterinary use

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